Vivori
Generic Name: Voriconazole
Dosage Form: Tablet
TG Name: Skin Care
1. What is VIVORI®?
VIVORI® (Voriconazole) is a triazole antifungal medication used to treat serious fungal infections.
2. How VIVORI® works in our body?
VIVORI® (Voriconazole) binds and inhibits ergosterol synthesis by inhibiting CYP450-dependent 14-alpha sterol demethylase. The inhibition of 14-alpha sterol demethylase results in a depletion of ergosterol in fungal cell membrane.
3. What are the indications of VIVORI®?
VIVORI® (Voriconazole) is an azole antifungal indicated for use in the treatment of:
- Invasive aspergillosis
- Candidemia (nonneutropenics) and disseminated candidiasis in skin, abdomen, kidney, bladder wall, and wounds
- Esophageal candidiasis
- Serious infections caused by Scedosporium apiospermum and Fusarium species including Fusarium solani, in patient’s intolerant of, or refractory to, other therapy
4. What is the dosage & administration of VIVORI®?
VIVORI® tablet is to be taken at least one hour before or one hour following a meal.
- At or over 40 Kg body weight is loading dose regimen is 400 mg or 10 ml every 12 hours (for the first 24 hours) and maintenance dose (after first 24 hours) is 200 mg or 5 ml twice daily.
- Below 40 Kg body weight is loading dose regimen is 200 mg or 5 ml every 12 hours (for the first 24 hours) and maintenance dose (after first 24 hours) is 100 mg or 2.5 ml twice daily.
5. What are the contraindications of VIVORI®?
- Hypersensitivity to Voriconazole or its excipients.
- Co-administration with terfenadine, astemizole, cisapride, pimozide or quinidine, sirolimus due to risk of serious adverse reactions.
- Co-administration with rifampin, carbamazepine, long-acting barbiturates, efavirenz, ritonavir, rifabutin, ergot alkaloids, and St. John’s Wort due to risk of loss of efficacy
6. What are the adverse effects of VIVORI®?
Most common adverse reactions (incidence ≥ 2%): visual disturbances, fever, nausea, rash, vomiting, chills, headache, liver function test abnormal, tachycardia, hallucinations.
7. What would be the storage condition of VIVORI®?
Do not store above 30°C. Do not refrigerate or freeze. Keep in a dry place. Protect from light & keep out of the reach of children.
