VIR

Entecavir

ANTIVIRAL » ANTIVIRALS » ANTIRETROVIRALS

INDICATION

VIR is indicated for the treatment of chronic hepatitis B Virus infection in adults with evidence of active viral replication and either evidence of persistent elevation in serum  aminnotransferases (ALT or AST) or histologically active disease.

DOSAGE AND ADMINISTRATION

The recommended dose of Entecavir for chronic hepatitis B virus infection in nucleoside-treatment naive adults and adolescents 16 years on an empty stomach (at least 2 hours after a meal or 2 hours before the next meal) is 0.5 mg daily.

Dose Adjustment in Renal impairment: Dose adjustment is recommended for patients with creatinine clearance <50 mL/min, including patients on hemodialysis or continuous ambulatory peritoneal dialysis (CAPD) as shown in below –

Dosing interval adjustment of Vir in patients with renal impairment
Creatinine clearance (mL/min)	³50	30 to <50	10 to <30	<10 Hemodialysis or CAPD
Recommended dose and dosing interval	0.5 mg every 24 hours	0.5 mg every 48 hours	0.5 mg every 72 hours	0.5 mg every 7 days

OR AS DIRECTED BY THE PHYSICIAN.

COMPOSITION

Each film-coated tablet contains Entecavir INN 0.5 mg.