Terbifin (Terbinafine)

Therapeutic Group : Antifungal

Presentation:

Terbifin Tablet: Each tablet contains Terbinafine Hydrochloride INN equivalent to Terbinafine 250 mg.
Terbifin Cream: Each gram contains Terbinafine Hydrochloride INN 10 mg.

Indications:

Terbifin Tablet: Dermatophyte infections of the nails, ringworm infections (including tinea pedis, crusis and corporis) where oral therapy is appropriate (due to site, severity and extent).
Terbifin Cream: Dermatophyte infections of the skin and hair, pityriasis (tinea) versicolor and yeast infections of the skin.

Other uses:
>Non-dermatophyte nail infections
>Systemic mycoses with dimorphic and rare mold fungi.

Dosage & Administration:

Terbifin Tablet:
Child: Usually for 2 weeks, tinea capitis, over 1 year, body-weight 10-20kg, 62.5 mg once daily; body-weight 20-40kg, 125 mg once daily; body-weight over 40 kg, 250 mg once daily.
Terbifin Cream:
Applied once or twice daily in:
Application of Terbifin Cream:
Clean and dry the affected areas thoroughly before application of Terbifin. Apply the cream to the affected skin and surrounding area in a thin layer and rub it lightly. In case of intertriginous infections (submammary, interdizital, intergluteal, inguinal) the application may be covered with a gauze strip, especially at night. Wash the hands thoroughly after application.

Contrainidications:

Hypersensitivity to Terbinafine or any of the excipients contained in the tablet or cream.

Warning & Precautions:

Warnings:
Good general hygiene is necessary in conjunction with the use of Terbinafine in order to prevent reinfection (e.g. from underwear, socks, shoes etc.).

Precautions:
Terbifin® cream is for external use only. Contact with eyes should be avoided.

Side effects:

Terbifin® Tablet:
Abdominal discomfort, anorexia, nausea, diarrhoea, headache, rash and urticaria occasionally with arthralgia or myalgia. Less frequently taste disturbance. Rarely liver toxicity, photosensitivity, serious skin reactions etc.

Terbifin® Cream:
Redness, itching or stinging; rarely allergic reactions.

Drug interaction:

Terbifin Tablet: Plasma concentration of terbinafine is increased by Rifampicin. Plasma concentration of terbinafine is decreased by Cimetidine.

Use in special groups:

Use in pregnancy and lactation:
Pregnancy category B. Treatment with Terbinafine is not recommended in nursing mothers.
Use in Children: Terbifine cream appears to be an effective and well-tolerated treatmenr of tinea corposis and tinea cruris in children.
Use in Elderly: Terbinafine appears to be safe in the elderly. The dose should be reduced by half if significant hepatic or renal impairment is present.

Storage:

Store below 30^o C and dry place, protect from light. Keep out of the reach of children.

Packing:

Terbifin® Tablet: Each box contains 12 tablets in Alu-Alu blister pack.
Terbifin® Cream: Each Tube contains 5g / 10g cream.