Tamlosin

DRUG FOR URINARY RETENTION: Tamsulosin Hydrochloride

Indication

Tamlosin is used in Benign Prostatic Hyperplasia. It relaxes smooth muscle in benign prostatic hyperplasia producing an increase in urinary flow-rate and an improvement in obstructive symptoms.

Contraindication

Tamsulosin should be avoided in-patients with a history of orthostatic hypotension and micturition syncope.

Dosage & Administration

Tamlosin tablet once daily is recommended as the dose for the treatment of the signs and symptoms of BPH. It should be administered approximately one-half hour following the same meal each day. For those patients who fail to respond to the 0.4 mg dose after two to four weeks of dosing, the dose of Tamlosin tablet can be increased to 0.8 mg once daily. If Tamlosin administration is discontinued or interrupted for several days at either the 0.4 mg or 0.8 mg dose, therapy should be started again with the 0.4 mg once daily dose.

Side Effect

The following adverse reactions have been reported during the use of Tamsulosin: dizziness, abnormal ejaculation, and less frequently (1-2%) headache, asthenia, postural hypotension, palpitations etc.

Drug Interaction

No interactions have been seen when Tamsulosin was given concomitantly with either atenolol, enalapril, nifedipine or theophylline. Concomitant cimetidine brings about a rise in plasma levels of Tamsulosin, and frusemide a fall, but as levels remain within the normal range dose change may not be required. There is a risk of enhanced hypotensive effect when given concurrently with drugs which may reduce blood pressure, including anaesthetic agents and other alpha1 adrenoceptor antagonists.

Use Children

Tamsulosin is not recommended for children

Use Pregnancy Lactation

Pregnancy Category B.

Storage

Store below 30 °C & in a dry place.