Oclazid

ANTIDIABETICS: Gliclazide

Indication

Oclazid & Oclazid MR are indicated  for the treatment of type-2 (non-insulin dependent) diabetes when diet, exercise and weight loss have failed to control the blood sugar.

Contraindication

Gliclazide should not be used in Juvenile-onset (type-1) diabetes, diabetes associated with Ketosis, diabetic patients undergoing surgery; after severe injury or during infection, patients having hypersensitivity for sulfonylurea.

Dosage & Administration

Oclazid: The usual initial dose is    to 1 tablet (40 to 80 mg) daily, gradually increasesed, if necessary, upto 4 tablet (320 mg). Doses of more than 160 mg daily are given in 2 divided doses. 

Oclazid  MR: The usual initial dose is 1 tablet (30 mg) once daily, gradually increased, if necessary, upto a maximum 4 tablets (120 mg) daily. It  is recommended  that the  drug  should  be taken  at  breakfast time.

Side Effect

There are generally mild and infrequent side effects including hypoglycaemia, gastro-intestinal disturbances, headache, skin rashes etc.

Precaution

Care  should  be  exercised  with  patients  having  hepatic  and  or  renal  impairment  and  a small starting dose should be used with careful patient monitoring. In long term clinical trials, patients with renal insufficiency have been treated satisfactorily using Gliclazide at reduced doses

Drug Interaction

Certain drug as such as aspirin, antibacterial sulphonamides, beta-blockers, diazepam, tetracyclines, miconazole may increase the hypoglycaemic effect of Gliclazide. Oral contraceptives, rifampicin, barbiturates, corticosteroids may oppose the activity of gliclazide.

Presentation

Oclazid: Box containing 5×10 tablets in blister strips. 

Oclazid MR: Box containing 3×10 tablets in blister strips.