Liftear (Lifitegrast INN)

Therapeutic Group : Immunomodulator & LFA-1 Antagonist

Presentation:

Liftear Ophthalmic Solution: Each ml contains Lifitegrast INN 50 mg
Preservative: Sodium Perborate BP 0.01%

Pharmacology:

Lifitegrast is a novel lymphocyte function associated antigen 1 (LFA-1) antagonist. It
acts by inhibiting LFA-1 interaction with the intercellular adhesion molecule (ICAM)-1
on the T-cell surface, inhibiting T-cell adhesion, migration, activation and subsequent
cytokine release and thereby inhibiting subsequent T-cell-mediated inflammation
associated with Dry Eye Disease.

Indications:

Lifitegrast is approved by USFDA for the treatment of the signs and symptoms of Dry
Eye Disease (DED).

Dosage & Administration:

Instill one drop in the affected eye(s) twice daily (approximately 12 hours apart).

Contrainidications:

Lifitegrast ophthalmic solution is contraindicated in patients who are hypersensitive
to any component of this product.

Warning & Precautions:

– For ophthalmic use only
– To avoid possible contamination of the drops, do not touch the dropper tip or to
any surface
– If more than one topical ophthalmic drug is being used, the drugs should be
administered at least five (5) minutes between applications
– Contact lenses should be removed prior to the administration of Lifitegrast and
may be reinserted 15 minutes following administration

Side effects:

The most common adverse reactions were instillation site irritation, dysgeusia and
decreased visual acuity.

Use in special groups:

Use in pregnancy: There are no adequate data and well-controlled studies in
pregnant women. Lifitegrast ophthalmic solution should be used during pregnancy
unless the potential benefit justifies the potential risk to the fetus.
Use in lactation: It is not known whether Lifitegrast is excreted in human milk.
Caution should be exercised while giving this ophthalmic solution to a nursing
mother.
Use in children: Safety and efficacy in pediatric patients below the age of 17 years
have not been established.
Use in geriatric patients: No overall differences in safety or effectiveness have been
observed between elderly and younger adult patients.

Packing:

Liftear Ophthalmic Solution: Each LDPE dropper bottle contains 5 ml sterile &
pyrogen free ophthalmic solution.