Hepamarin-140 (Silymarin)

Therapeutic Group : Herbal

Pharmacology:

Silymarin possesses hepatoprotective and antioxidant activity. The hepatoprotective effect is due to the stimulation of synthesis of structural and functional proteins and phospholipids, as well as the acceleration of the regeneration of hepatocytes. The antioxidant effect is determined by bioflavonoids’ interaction with free radicals in the liver and its detoxication. In such a manner, the process of peroxidation of the lipids is interrupted and further liver destruction is prevented. Clinically, these effects are manifested by improving the signs and symptoms and normalization of the liver variables (serum level of transaminases, gamma-globulins and bilirubin).

Indications:

• Jaundice
• Hepatitis
• Liver damage
• Liver cirrhosis

Dosage & Administration:

One Hepamarin-140 capsule should be taken 3 times daily or as directed by the physician. The medication should be continued until the relief of the symptoms according to the advice of a physician.

Contrainidications:

Patients who have hypersensitivity to Silymarin.
WARNING & PRECAUTION: Avoid excess dosage.

Warning & Precautions:

A mild laxative effect has occasionally been observed.

Drug interaction:

Side effects:

No significant interactions are found.
OVERDOSE: Clinically safe up to 1200 mg/day

Use in special groups:

USE IN PREGNANCY & LACTATION:
Milk thistle has traditionally been used in pregnancy. Limited clinical studies in pregnancy demonstrate use without apparent adverse effects. Caution should be used in pregnant and breastfeeding women.
USE IN CHILDREN & ADOLESCENTS
No adequate data of investigations are available about the use of this drug in children. Therefore, it should be used in children under 12 years of age with caution under the direct supervision of a physician.

Storage:

Store below 30°C, keep in dry place and protect from light. Keep out of the reach of children.