Axim CV

Axim CV (Cefuroxime + Clavulanic Acid)

Axim CV

Therapeutic Group : Antibiotic

Presentation:

Axim CV 250 Tablet: Each film coated tablet contains Cefuroxime Axetil USP equivalent to Cefuroxime 250 mg and Diluted Potassium Clavulanate BP equivalent to Clavulanic Acid 62.50 mg.

Axim CV 500 Tablet: Each film coated tablet contains Cefuroxime Axetil USP equivalent to Cefuroxime 500 mg and Diluted Potassium Clavulanate BP equivalent to Clavulanic Acid 125 mg.

Axim CV Powder for Suspension: After reconstitution each 5 ml suspension contains Cefuroxime Axetil USP equivalent to Cefuroxime 125 mg and Diluted Potassium Clavulanate BP equivalent to Clavulanic Acid 31.25 mg.

Indications:

Axim CV is indicated for the treatment of the following infections caused by susceptible microorganisms:
– Pharyngitis/Tonsillitis caused by Streptococcus pyogenes
– Acute Bacterial Otitis Media caused by Streptococcus pneumoniae, Haemophilus influenzae(including beta-lactamase-producing strains), Moraxella catarrhalis(including beta-lactamase-producing strains), or Streptococcus pyogenes
– Acute Bacterial Maxillary Sinusitis caused by Streptococcus pneumoniae or Haemophilus influenzae(non-beta-lactamase-producing strains only)
– Acute Bacterial Exacerbations of Chronic Bronchitis and Secondary Bacterial Infections of Acute Bronchitis caused by Streptococcus pneumoniae, Haemophilus influenzae(beta-lactamase negative strains), or Haemophilus parainfluenzae(beta-lactamase negative strains)
– Uncomplicated Skin and Skin-Structure Infections caused by Staphylococcus aureus(including beta-lactamase-producing strains) or Streptococcus pyogenes
– Uncomplicated Urinary Tract Infections caused by Escherichia coli or Klebsiella pneumoniae.
– Uncomplicated Gonorrhea (urethral and endocervical) caused by penicillinase-producing and non-penicillinase-producing strains of Neisseria gonorrhoeae and uncomplicated gonorrhea, (rectal) in females, caused by non-penicillinase-producing strains of Neisseria gonorrhoeae.
– Lyme disease (erythema migrans) caused by Borrelia burgdorferi.
– Septicemia caused by Staphylococcus aureus, Streptococcus pneumoniae, Escherichia coli, Haemophilus influenzae(including ampicillin-resistant strains) & Klebsiella spp.
– Meningitis caused by Streptococcus pneumoniae, Haemophilus influenzae(including ampicillin-resistant strains), Neisseria meningitidis & Staphylococcus aureus(penicillinase and non-penicillinase producing strains)
– Switch therapy (Injectable to oral)

Dosage & Administration:

PatientsIndicationsDosageDuration (Days)
Adolescents and Adults (13 years and older)Pharyngitis/tonsillitis250 mg twice daily5-10
Acute bacterial maxillary sinusitis250 mg twice daily10
Acute bacterial exacerbations of chronic bronchitis250-500 mg twice daily10
Secondary bacterial infections of acute bronchitis250-500 mg twice daily5-10
Uncomplicated skin and skin-structureinfections250-500 mg twice daily10
Uncomplicated urinary tract infections250 mg twice daily7-10
Uncomplicated gonorrhea1000 mgSingle Dose
Community acquired pneumonia250-500 mg twice daily5-10
MDR Typhoid fever500 mg twice daily10-14
Lyme disease500 mg twice daily20
Pediatric Patients(3 months to 12 years)Pharyngitis/tonsillitis20 mg/kg/day in 2 divided dose5-10
Acute otitis media30 mg/kg/day in 2 divided dose10
Acute bacterial maxillary sinusitis30 mg/kg/day in 2 divided dose10
Uncomplicated skin & skin-structure infections30 mg/kg/day in 2 divided dose10
Community acquired pneumonia30 mg/kg/day in 2 divided dose5-10
MDR Typhoid fever30 mg/kg/day in 2 divided dose10-14
Uncomplicated urinary tract infection20 mg/kg/day in 2 divided dose7-10

Direction for reconstitution of suspension:
Shake the bottle well to loosen the powder. Add 60 ml of boiled and cooled water to the dry powder of the bottle. Then shake the bottle well until all the powder is in suspension. The reconstituted suspension must be kept in 2° and 8° C temperature in a refrigerator and should be used within 7 days after reconstitution.

Contrainidications:

Cefuroxime-Clavulanic Acid is contraindicated in patients with known allergy to cephalosporin & in patients with Pseudomembranous Colitis.

Warning & Precautions:

Cefuroxime-Clavulanic Acid should be given with care to patients receiving concurrent treatment with potent diuretics & who have history of Pseudomembranous Colitis.

Side effects:

Generally Cefuroxime-Clavulanic Acid is well tolerated. However, a few side effects like nausea, vomiting, diarrhea, abdominal discomfort or pain may occur. As with other broad-spectrum antibiotics, prolonged administration of Cefuroxime and Clavulanic acid combination may result in overgrowth of nonsusceptible microorganisms. Rarely (<0.2%) renal dysfunction, anaphylaxis, angioedema, pruritis, rash and serum sickness like urticaria may appear.

Drug interaction:

Concomitant administration of probenecid with Cefuroxime-Clavulanic Acid increases the area under the serum concentration versus time curve by 50%. Drug that reduces gastric acidity may result in a lower bioavailability of Cefuroxime and tend to cancel the effect of postprandial absorption.

Use in special groups:

Use in pregnancy: While all antibiotics should be avoided in the first trimester if possible. However, Cefuroxime-Clavulanic Acid can be safely used in later pregnancy to treat urinary and other infections.
Use in lactation: Cefuroxime-Clavulanic Acid is excreted into the breast milk in small quantities. However, the possibility of sensitizing the infant should be kept in mind.

Packing:

Axim CV 250 Tablet: Each box contains 12 tablets in Alu-Alu blister within Alu-Alu pillow pack
Axim CV 500 Tablet: Each box contains 8 tablets in Alu-Alu blister within Alu-Alu pillow pack
Axim CV Powder for Suspension: Bottle containing dry powder for the reconstitution of 70 ml suspension.