Acyvir (Acyclovir)

Acyclovir is a synthetic purine neucleotide analogue, which acts against human herpes viruses.

Description

Acyclovir is a synthetic purine neucleotide analogue, which acts against human herpes viruses. The enzyme thymidine kinase (TK) encoded by HSV, VZV and EBV converts acyclovir into acyclovir monophosphate, a neucleotide analogue, which is further converted to diphosphate and triphosphate by cellular enzymes. Acyclovir triphosphate interferes with DNA polymerase and inhibits viral DNA replication with resultant chain termination following its incorporation into the growing viral DNA chain.

Presentation

Acyvir Eye Ointment: Each gram ointment contains Acyclovir USP 30 mg.

Indications

Acyvir eye ointment is indicated for treatment of Herpes Simplex Keratitis.

Dosage & Administration

Apply ointment into lower conjunctival sac five times daily at 4 hours interval; continue for minimum 3 days after healing.

Contrainidications

It is contraindicated to the patients with known hypersensitivity to acyclovir.

Warning & Precautions

Side effects

Transient mild stinging immediately following application may occur in a small proportion of patients. Local irritation and inflammation such as blepharitis and conjunctivitis have also been reported.

Drug interaction

Use in special groups

Use in pregnancy & lactation: The use of Acyclovir sterile eye ointment should be considered only when the potential benefits outweigh the possibility of unknown risk.

Packing

Acyvir Eye Ointment: Each tube contains 5 g sterile eye ointment.