Cefditor

ANTIBIOTICS: Cefditoren

Indication

Cefditor Tablets are indicated in the treatment of mild to moderate infections in adults and adolescents (12 years of age or older), which are caused by susceptible strains of the designated microorganisms in the conditions listed below:

Acute Bacterial Exacerbations of Chronic Bronchitis (ABECB) caused by Haemophilus influenzae (including beta-lactamase-producing strains), Haemophilus parainfluenzae (including beta-lactamase-producing strains),Streptococcus pneumoniae (penicillin-susceptible strains only), or Moraxella catarrhalis (including beta-lactamase-producing strains).

Community-Acquired Pneumonia (CAP) caused by Haemophilus influenzae (including beta-lactamase-producing strains), Haemophilus parainfluenzae (including beta-lactamase-producing strains), Streptococcus pneumoniae (penicillin-susceptible strains only), or Moraxella catarrhalis (including betalactamase- producing strains).

Pharyngitis/Tonsillitis caused by Streptococcus pyogenes.

Uncomplicated Skin and Skin-Structure Infections caused by Staphylococcusaureus (including beta-lactamase-producing strains) or Streptococcus pyogenes. 

Dosage & Administration

Adults:

ABECB: 400mg bid for 10 days. Pharyngitis/Tonsillitis/SSSI: 200mg bid for 10 days.

CAP: 400mg bid for 14 days. Take with meals.

Pediatrics: 12 yrs: 

ABECB: 400mg bid for 10 days.

Pharyngitis/Tonsillitis/SSSI: 200mg bid for 10 days. 

CAP: 400mg bid for 14 days. 

Side Effect

Most adverse events are mild and self-limiting. No deaths or permanent disabilities have been attributed to cefditoren.

Other adverse events reported are abnormal dreams, allergic reaction, anorexia, asthenia, asthma, coagulation time increased, constipation, dizziness, dry mouth, eructation, face edema, fever, flatulence, fungal infection, gastrointestinaldisorder, hyperglycemia, increased appetite, insomnia, leukopenia, leukorrhea, liver function test abnormal, myalgia, nervousness, oral moniliasis, pain, peripheral edema, pharyngitis, pseudomembranous colitis, pruritus, rash, rhinitis, sinusitis, somnolence, stomatitis, sweating, taste perversion, thirst, thrombocythemia, urticaria, and vaginitis. Pseudomembranous colitis symptoms may begin during or after antibiotic treatment.The overall incidence of adverse events, particularly diarrhea, increased with the higher recommended dose of cefditoren.

Drug Interaction

Co-administration of a single dose of an antacid and H2 receptor antagonists may reduce the oral absorption of cefditoren pivoxil. As with other beta-lactam antibiotics, co-administration of probenecid with cefditoren pivoxil resulted in an increase in the plasma exposure of cefditoren.

Preparation

Cefditor 200 mg tablet: Each tablet contains Cefditoren INN 200 mg.