Xclor

ANTIBIOTICS: Cefaclor Monohydrate

Indication

Otitis Media, Lower Respiratory Tract Infections, including Pneumonia, Bronchitis and Acute Exacerbation of Chronic Bronchitisn, Upper Respiratory Tract Infections, including Pharyngitis and Tonsillitisn Urinary Tract Infections, including Pyelonephritis and Cystitisn Skin and Soft Tissue Infections (SSTIs)n Skin and Skin Structure Infections (SSSIs), Sinusitis

Contraindication

Xclor (Cefaclor) is contraindicated in patients with known allergy to the Cephalosporin group of antibiotics.

Dosage & Administration

Adults: The usual adult dosage is 250 mg every 8 hours. For more severe infections (such as Pneumonia) or those caused by less susceptible organisms, doses may be doubled.

Pediatric Patients: The usual recommended daily dose for pediatric patients is 20 mg/kg/day in divided doses every 8 hours. In more serious infections, Otitis Media, and infections caused by less susceptible organisms, 40 mg/kg/day are recommended, with a maximum dose of 1 gm/day.

Side Effect

Gastrointestinal symptoms occur in about 2.5 % of patients including diarrhoea (1 in 70). Symptoms of pseudomembranous colitis may appear either during or after antibiotic treatment. Nausea and vomiting have been reported rarely.

As with some penicillin and some other Cephalosporins, transient hepatitis and cholestatic jaundice have been reported rarely.

Drug Interaction

There have been reports of increased anticoagulant effect when Xclor (Cefaclor) and oral anticoagulants were administered concomitantly. As with other beta-lactam antibiotics, the renal excretion of Cefaclor is inhibited by Probenecid.

Presentation

Xclor suspension: Bottle containing dry powder for 100 ml suspension after reconstitution and a  10 ml measuring cup.