Zafirlukast Indications Accolate is indicated for the prophylaxis and chronic treatment of asthma in adults and children 5 years of age and older. Pharmacology Zafirlukast is a selective and competitive leukotriene-receptor antagonist (LTRA) of leukotriene D4 and E4 (LTD4 and LTE4), components of slow-reacting substance of anaphylaxis (SRSA). Cysteinyl leukotriene production and receptor occupation have […]