Generic Name :Oxaliplatin Indications Xaloplat, used in combination with infusional 5-fluorouracil/folinic acid, is indicated for: Pharmacology Oxaliplatin undergoes nonenzymatic conversion in physiologic solutions to active derivatives via displacement of the labile oxalate ligand. Several transient reactive species are formed, including monoaquo and diaquo DACH platinum, which covalently bind with macromolecules. Both inter-and intrastrand Pt-DNA crosslinks […]