Description Tofacitinib is an oral Janus kinase (JAK) inhibitor for the treatment of rheumatoid arthritis and psoriatic arthritis. Tofacitinib inhibits JAK dependent cytokinesignaling. JAKs are intracellular enzymes which transmit signals arising from cytokine or growth factor-receptor interactions on the cellular membrane. JAKsphosphorylate and activate Signal Transducers and Activators of Transcription (STATs) which modulate intracellular activity […]
Description Tofacitinib is an oral Janus kinase (JAK) inhibitor for the treatment of rheumatoid arthritis and psoriatic arthritis. Tofacitinib inhibits JAK dependent cytokinesignaling. JAKs are intracellular enzymes which transmit signals arising from cytokine or growth factor-receptor interactions on the cellular membrane. JAKsphosphorylate and activate Signal Transducers and Activators of Transcription(STATs) which modulate intracellular activity including […]
TofacitinibSpecial Anti-rheumatic Agents (Special Anti-rheumatic Agents) Indication: Rheumatoid Arthritis: Tofacitinib is indicated for the treatment of adult patients with moderately to severely active Rheumatoid Arthritis who have had an inadequate response or intolerance to Methotrexate. It may be used as monotherapy or in combination with Methotrexate or other nonbiologic Disease-Modifying Antirheumatic Drugs (DMARDs). Psoriatic Arthritis: […]