Tizanidine Hydrochloride Indications Treatment of painful muscle spasms: Treatment of spasticity due to neurological disorders: Pharmacology Tizanidine is a centrally acting skeletal muscle relaxant. Its principal site of action is the spinal cord, where the evidence suggests that, by stimulating presynaptic alpha2 receptors, it inhibits the release of excitatory amino acids that stimulate N-methyl-D aspartate […]