Sitagliptin+Metformin DIABETES » DIPEPTIDYL PEPTIDASE-4 (DPP-4) INHIBITORS + BIGUANIDES INDICATION Type-2 diabetes mellitus. DOSAGE AND ADMINISTRATION The recommended starting dose in patients not currently treated with Metformin is 50 mg Sitagliptin/500 mg Metformin hydrochloride twice daily. The starting dose in patients already treated with Metformin should provide Sitagliptin dosed as 50 mg twice daily (100 […]