Bisoprolol and HCTZ have been used individually and in combination for the treatment of hypertension. Description Bisoprolol and HCTZ have been used individually and in combination for the treatment of hypertension. The antihypertensive effects of these agents are additive; HCTZ 6.25 mg significantly increases the antihypertensive effect of Bisoprolol. The incidence of hypokalemia with the […]