Metformin HClBiguanide Preparation (Antidiabetic Preparations) Indication: Management of type 2 diabetes mellitus. Dosage & Administration: Adults : Starting dose of Comet® (Metformin Hydrochloride Tablet) is 500 mg twice a day or 850 mg once a day, given with meals. Dosage increases should be made in increments of 500 mg weekly or 850 mg every 2 weeks, […]