Pheramin Tablet
Chlorpheniramine Maleate
Indications
Pheramin is indicated in the following indications-
- Urticaria
- Sensitivity reactions
- Angioneurotic edema
- Vasomotor rhinitis
- Cough
- Common cold
- Motion sickness and
- Other allergic conditions.
Pharmacology
Chlorpheniramine Maleate is an alkylamine antihistamine. It is one of the most potent histamine H1-receptor blocking agents which is used as a potent antihistamine. This generally causes less sedation than promethazine. Chlorpheniramine Maleate exerts its effects by blocking H1-receptor competitively.
Dosage & Administration
Adult- Usual adult dose is 4 mg every 4-6 hours, maximum 24 mg daily.
Child-
- 6-12 years: 2 mg every 4-6 hours, maximum 12 mg daily.
- 2-5 years: 1 mg every 4-6 hours, maximum 6 mg daily.
- 1-2 years: 1 mg twice daily.
Below 1 year the use of Chlorpheniramine Maleate is not recommended.
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Interaction
Chlorphenamine maleate has been reported to be incompatible with calcium chloride, kanamycin sulfate, noradrenaline acid tartrate, pentobarbital sodium, and meglumine adipiodone.
Contraindications
Chlorpheniramine is contraindicated in patients hypersensitive to this agent, in newborn or premature infants.
Side Effects
Pheramin is well-tolerated, but sometimes drowsiness, dizziness, muscular weakness, and gastrointestinal upset may occur.
Pregnancy & Lactation
This drug should not be used in lactating mother and in pregnancy especially during the first trimester of pregnancy.
Precautions & Warnings
Pheramin should be used with caution in patients with glaucoma and prostatic hypertrophy. During therapy with chlorpheniramine, caution should be taken in driving vehicles and operating machinery.
Overdose Effects
CNS depression (including sedation, apnea, CV collapse), CNS stimulation (including insomnia, hallucination, tremors, convulsions), tinnitus, blurred vision, dizziness, ataxia, hypotension. Stimulation and atropine-like signs and symptoms (including dry mouth, fixed dilated pupils, flushing, hyperthermia, Gl symptoms) are more likely in children.
Therapeutic Class
Sedating Anti-histamine
Storage Conditions
Store in a cool (Below 25°C temperature) and dry place protected from light. Keep out of the reach of children.
