Parakil Plus Vet(Ivermectin)
Therapeutic Group: Anthelmintic
Presentation
Parakil Plus vet Injection: Each ml injectable solution contains Ivermectin BP 10 mg &Clorsulon USP 100 mg.
Description
Ivermectin is a derivative of Avermectins, a family of potent broad-spectrum anthelmintic. Ivermectin binds selectively with high affinity to glutamate-gated chloride ion channels results in the permeability of the cell membrane to chloride ions with hyperpolarization of the nerve or muscle cell, causing paralysis and death of the parasite. It is reliable, long-lasting parasite controller of cattle for effective treatment and control of internal and external parasitic infections and for protecting animals from re-infection. Clorsulon is a drug of benzene sulphonamides family work as flukicide. Clorsulon kills parasites by inhibiting the enzymes involved in the glycolytic pathway, the primary source of energy of flukes. It also depress the ATP level in the flukes.
Indications
Parakil Plus is indicated for the treatment, control and protect animal from re-infection of the following parasites-
Gastrointestinal Roundworms (adult and fourth-stage larvae): Ostertagiaostertagi, Haemonchusplacei, Trichostrongylusaxei, T. colubriformis, Cooperiaoncophora, C. punctata, C. pectinata, Oesophagostomumradiatum, Bunostomumphlebotomum, Nematodirushelvetianus (adults only) & N. spathiger (adults only).
Lungworms (adults and fourth-stage larvae): Dictyocaulus viviparous
Grubs (parasitic stages): Hypodermabovis& H. lineatum
Sucking Lice: Linognathusvituli, Haematopinuseurysternus&Solenopotescapillatus
Mites (scabies): Psoroptesovis (syn. P. communis var. bovis) &Sarcoptesscabiei var. bovis
Liver fluke: Fasciola hepatica (Adults only)
Dosage & Administration
Injection Parakil Plus vet should be injected only by subcutaneous route (under the loose skin in front of or behind the shoulder).
Cattle, buffalo, goat, sheep & horse: 1 ml/50 kg (Ivermectin 0.2 mg &Clorsulon 2 mg/kg) body weight (single injection). In case of humpsore in cattle the dose may be repeated after 28 days.
Or as directed by the registered Veterinarian
Side Effects
The combination is well tolerated at recomended dose. However, a low incidence of soft tissue swelling at the injection site may be observed. These reactions will disappear without any treatment within 30 min-1 hour.
Precautions
This combination should not be used in intravenous or intramuscular route.
Use in Pregnancy & Lactation
Safe in pregnant and lactating animal.
Drug Interaction
Barbiturates (such as Phenobarbital, Butalbital), benzodiazepines (such as Clonazepam, Diazepam, Lorazepam), Sodium Oxybate (GHB) and Valproic acid have drug interactions with Ivermectin injection. In that case caution should be applied before using with upper mentioned drugs.
Over Dose
10 times safe in ruminants. However, hives, tingling of feet, weakness, loss of coordination, stomach pain, vomiting, diarrhea, difficult breathing may be reported.
Withdrawal Period
Meat: 21 days & Milk: Sufficient information is not available.
Storage
Do not store above 30°C, avoid freezing. Store the vial in the carton to protect from light. Keep out of the reach of children.
Commercial Pack
Parakil Plus vet Injection 10 ml: Each commercial box contains 1 vial of 10 ml.
