Oxizol(Oxiconazole)
Therapeutic Group: Antifungal Agent
Presentation
Oxizol Cream: Each gram cream contains Oxiconazole Nitrate INN equivalent to Oxiconazole 10 mg.
Oxizol Lotion: Each gram lotion contains Oxiconazole Nitrate INN equivalent to Oxiconazole 10 mg.
Description
Oxiconazole Nitrate is an imidazole derivative whose antifungal activity is derived primarily from the inhibition of ergosterol biosynthesis, which is critical for cellular membrane integrity. It has in vitro activity against a wide range of pathogenic fungi.
Indications
Oxiconazole cream and lotion are indicated for the topical treatment of the following dermal infections: tinea pedis, tinea cruris, and tinea corporis due to Trichophyton Rubrum, Trichophyton Mentagrophytes, orEpidermophyton Floccosum. Oxiconazole is also indicated for the topical treatment of tinea (pityriasis) versicolor due to Malassezia Furfur.
Dosage & Administration
Oxiconazole cream and lotion should be applied to affected and immediately surrounding areas once to twice daily in patients with tinea pedis, tinea corporis, or tinea cruris. Oxiconazole cream should be applied once daily in the treatment of tinea (pityriasis) versicolor. Tinea corporis, tinea cruris, and tinea (pityriasis) versicolor should be treated for 2 weeks and tinea pedis for 1 month to reduce the possibility of recurrence.
If a patient shows no clinical improvement after the treatment period, the diagnosis should be reviewed.
Pediatric Use: Oxiconazole cream may be used in pediatric patients for tinea corporis, tinea cruris, tinea pedis, and tinea (pityriasis) versicolor; however, these indications for which Oxiconazole cream has been shown to be effective rarely occur in children below the age of 12.
Geriatric Use: No adverse events were reported with Oxiconazole lotion in geriatric patients, and the adverse reactions reported with Oxiconazole cream in this population were similar to those reported by younger patients. Based on available data, no adjustment of dosage of Oxiconazole cream and lotion in geriatric patients is warranted.
Administration Procedure
Cream: Clean and thoroughly dry the area to be treated. Apply this medication to the affected skin, usually once or twice a day or as directed by physician.
Lotion: Before using Lotion, the affected area should be clean and dry. Lotion should be applied to the affected area. Lotion should be used for the amount of time indicated by physician.
Side Effects
The Side effects include pruritus, burning, irritation and allergic contact dermatitis, folliculitis, erythema and papules, fissure, maceration, rash, stinging, and nodules. For Lotion Side effects include burning and stinging, pruritus, scaling, tingling, pain, and dyshidrotic eczema.
Precautions
If a reaction suggesting sensitivity or chemical irritation occurs with the use of Oxiconazole cream or lotion, treatment should be discontinued and appropriate therapy should be instituted.
Use in Pregnancy & Lactation
Pregnancy: Pregnancy Category B, this drug should be used during pregnancy only if clearly needed.
Lactation: Because Oxiconazole is excreted in human milk, caution should be exercised when the drug is administered to a nursing woman.
Over Dose
No overdoses in humans have been reported with use of Oxiconazole Nitrate cream or lotion.
Storage
Do not store above 30 ºC. Keep away from light and out of the reach of children.
Commercial Pack
Oxizol Cream: Each tube contains 10 gm cream.
Oxizol Lotion: Each bottle contains 30 ml lotion.
