Lomeflox (Lomefloxacin)

Therapeutic Group : Antibiotic

Presentation:

Lomeflox Tablet: Each film coated tablet contains Lomefloxacin HCl INN equivalent to Lomefloxacin 400 mg.

Pharmacology:

Lomefloxacin, a difluorioniated quinolone derivative, is a bacterial gyrase inhibitor, effective against gram positive and gram-negative bacteria. Lomefloxacin interferes with bacterial DNA related processes like initiation, elongation and termination phases of replication, transcription, DNA repair, recombination, transposition, supercoiling and relaxation of DNA, resulting in a rapid killing of sensitive bacteria. Cross-resistance has only been reported with other quinolones, but not with any other group of antibiotics. No clinical studies are available about the efficacy in case infections with chlamydia.

Indications:

a) Treatment:
Uncomplicated urinary tract infections. Complicated including recurrent and pyelonephritis, urinary tract infections. Acute exacerbation of chronic bronchitis. Skin and skin structure infections.
b) Prevention/Prophylaxis:
Lomeflox (Lomefloxacin) is indicated preperatively to prevent postoperative urinary tract infections in patients undergoing transurethral surgical procedures.

Dosage & Administration:

Typhoid fever: 400 mg once daily or 200 mg b.i.d 10-14 days. UTI infections: Uncomplicated – 400 mg once daily or 200 mg b.i.d 3 days. Complicated – 400 mg once daily or 200 mg b.i.d 10-14 days. Bacterial Diarrhea : 400 mg once daily or 200 mg b.i.d 5-7 days. Acute exacerbation of chronic bronchitis : 400 mg once daily 7-10 days. Skin and skin structure infections : 400 mg once daily 10-14 days. Prophylaxis of UTI following surgery: 400 mg Single dose 2-6 hours prior to transurethral surgery.

Contrainidications:

Lomefloxacin is contraindicated in patients with a history of hypersensitivity to Lomefloxacin or to other quinolones. Lomefloxacin like other drugs in its class, cause arthropathy in juvenile animals. Therefore, its use in children, growing adolescents, and pregnant women is not recommended.

Warning & Precautions:

Alterations of the dosage regimen is recommended for patients with impairment of renal function (Ccr<40ml/min/1.73 sq.m). Avoid exposure to excessive sunlight or artificial UV light. Phototoxicity reaction may occur if undue exposure occurs. Safety and efficacy of Lomeflox (Lomefloxacin) has not been established in children, pregnant and lactating women.

Side effects:

Nausea, headache, photosensitivity, dizziness, diarrhea, dry mouth, fatigue, convulsions, CNS stimulation which may lead to tremors, restlessness, light headedness, confusion & hallucinations and pseudomembranous colitis.

Drug interaction:

Lomefloxacin does not alter theophylline clearance and concentration. No change of caffeine is reported. Sucralfate and antacid containing magnesium and aluminium interfere with its bioavailability. Enhances effects of warfarin. Probenecid slows renal elimination of Lomeflox (Lomefloxacin).

Packing:

Lomeflox Tablet: Each box contains 20\\\’s tablet in Alu-Alu blister pack.