Lodicard (Amlodipine + Atenolol)
Therapeutic Group : Cardiovascular
Presentation:
Lodicard Tablet : Each tablet contains Amlodipine besilate BP equivalent to Amlodipine 5 mg and Atenolol BP 50 mg.
Indications:
Lodicard is indicated for the following conditions: 1) For the treatment of hypertension 2) For chronic stable angina 3) In post MI patients 4) In patients with refractory angina pectoris where nitrate therapy has failed.
Dosage & Administration:
The usual daily dose is one tablet of Lodicard. However, the dose may be titrated depending on therapeutic response.
Contrainidications:
Hypersensitivity to either component, sinus bradycardia, second and higher degree of heart block, cardiogenic shock, hypotension, congestive heart failure, poor left ventricular function.
Warning & Precautions:
Impaired hepatic function: Caution may be necessary in the use of the combination in patients with severe liver damage because of prolongation of the elimination half- life of amlodipine. Impaired renal function: The combination can be used in patients with renal impairment. However, caution may be necessary if the creatinine clearance is less than 30 ml/min because of possible reduction in the excretion of unchanged atenolol.
Side effects:
The combination of amlodipine and atenolol is well tolerated. Side effects include headache, flushing, edema, dizziness, dyspepsia & fatigue.
Drug interaction:
Disopyramide: Atenolol reduces the clearance of disopyramide by 20%. Additive negative ionotropic effects on the heart may be produced. Ampicillin: At doses of 1 g and above may reduce atenolol levels. Insulin: Beta-blockers may decrease tissue sensitivity to insulin.
Use in special groups:
Pregnancy: The combination should be used during pregnancy only if the expected benefit outweighs the potential foetal risk.
Lactation: The combination should not be used by nursing mothers. If it use is considered necessary, breast feeding should be stopped.
Packing:
Lodicard Tablet :Each box contains 60’s tablets in blister pack.
