Doxoven

Generic Name:Doxophylline

Indications

Doxoven is used to treat in following indications: 

• Bronchial asthma,
• Bronchospasm,
• Chronic obstructive pulmonary disease (COPD),
• Pulmonary disease with spastic bronchial component.

Interaction

Doxoven should not be administered with other xanthine preparations. It is recommended to limit consumption of beverages and food containing caffeine. Caution should be exercised in administering Doxoven together with ephedrine or other sympathomimetic drugs. The concurrent administration of many drugs such as erythromycin, TAO, lincomycin, clindamycin, allopurinol, cimetidine, influenza vaccine and propanolol may reduce the hepatic clearance of xanthine derivatives with an increase in the plasmatic levels of the drug. Phenytoin, other anticonvulsants and cigarette smoking may increase the clearance of xanthine derivatives with a reduction of plasmatic half-life. In these cases, it may be necessary to increase the dosage of the drug.

Contraindications

Doxophylline is contraindicated in individuals with known hypersensitivity to the drug or other xanthine derivatives. It is also contraindicated in patients with acute myocardial infarction, hypotension and during lactation.

Side Effects

Patients treated with xanthine derivatives may suffer nausea, vomiting, epigastric pain, headache, irritability, insomnia, tachycardia, extrasystoles, tachypnea and in rare cases hyperglycemia or albuminuria. In case of overdose severe cardiac arrhythmias and tonic-clonic seizure may occur. These effects may represent the first signs of intoxication. The appearance of side effects may require discontinuation of the treatment which, if necessary, at the physician’s discretion, may be resumed at lower doses after all signs and symptoms of toxicity have subsided.

Pregnancy & Lactation

Pregnancy and Lactation: Animal tests have shown that the active ingredient of Doxophylline does not interfere with pre and postnatal growth. However, as there is not sufficient clinical evidence about the effects of the drug during pregnancy, use of the drug during pregnancy should be evaluated carefully case by case on the basis of the risk-benefit ratio. The drug is contraindicated during lactation.

Effects on ability to drive and use machines: The product does not affect the patient’s alertness and therefore does not interfere with his/her ability to drive and use machines.