Cerox CV Tablet
Cefuroxime Axetil + Clavulanic Acid
Indications
Cerox CV is indicated for the treatment of infections caused by sensitive bacteria.
- Pharyngitis/Tonsillitis caused by Streptococcus pyogenes.
- Acute Bacterial Otitis Media caused by Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis (beta-lactamase producing strains) or Streptococcus pyogenes.
Pharmacology
Cefuroxime is a bactericidal second generation cephalosporin antibiotic which is active against a wide range of Gram-positive and Gram-negative susceptible organisms including many beta-lactamase producing strains. Cefuroxime inhibits bacterial cell wall synthesis by interfering with the transpeptidation process.
Clavulanic acid is a naturally derived beta lactamase inhibitor produced by Streptomyces clavuligerus. It has similar structure to beta lactam antibiotics which binds irreversibly to beta-lactamase enzymes and inactivates them. Clavulanic acid gives protection of Cefuroxime from degradation by beta lactamase enzymes and provides a solution for the treatment of bacterial infections caused by beta lactam resistant bacteria.
Dosage & Administration
Adolescents and adults (13 years and older)-
- Pharyngitis/tonsillitis: 250 mg b.i.d. for 5-10 days
- Acute bacterial maxillary sinusitis: 250 mg b.i.d. for 10 days
- Acute bacterial exacerbation of chronic bronchitis: 250-500 mg b.i.d. for 10 days
- Secondary bacterial infections of acute bronchitis: 250-500 mg b.i.d. for 5-10 days
- Uncomplicated skin and skin structure infections: 250-500 mg b.i.d. for 10 days
- Uncomplicated urinary tract infections: 250 mg b.i.d. for 7-10 days
- Uncomplicated Gonorrhoea: 1000 mg b.i.d. Single dose
- Community acquired pneumonia: 250-500 mg b.i.d. for 5-10 days
- MDR Typhoid Fever: 500 mg b.i.d. for 10-14 days
- Early Lyme disease: 500 mg b.i.d. for 20 days
Paediatric Patients (3 months to 12 years)-
- Pharyngitis/Tonsillitis: 20 mg/kg/day b.i.d for 5-10 days
- Acute otitis media: 30 mg/kg/day b.i.d for 10 days
- Acute bacterial maxillary sinusitis: 30 mg/kg/day b.i.d for 10 days
- Impetigo: 30 mg/kg/day b.i.d for 10 days
Cefuroxime-Clavulanic Acid tablet may be taken without regard of food.
Interaction
Concomitant administration of probenecid with Cefuroxime-Clavulanic Acid increases the area under the serum concentration versus time curve by 50%. Drug that reduces gastric acidity may result in a lower bioavailability of Cefuroxime and tend to cancel the effect of postprandial absorption.
Contraindications
Cefuroxime-Clavulanic Acid is contraindicated in patients with known allergy to cephalosporin & in patients with Pseudomembranous Colitis.
Side Effects
Generally Cefuroxime-Clavulanic Acid is well tolerated. However, a few side effects like nausea, vomiting, diarrhea, abdominal discomfort or pain may occur. As with other broad-spectrum antibiotics, prolonged administration of Cefuroxime and Clavulanic acid combination may result in overgrowth of nonsusceptible microorganisms. Rarely (<0.2%) renal dysfunction, anaphylaxis, angioedema, pruritis, rash and serum sickness like urticaria may appear.
Pregnancy & Lactation
While all antibiotics should be avoided in the first trimester if possible. However, Cefuroxime-Clavulanic Acid can be safely used in later pregnancy to treat urinary and other infections. Cefuroxime-Clavulanic Acid is excreted into the breast milk in small quantities. However, the possibility of sensitizing the infant should be kept in mind.
Precautions & Warnings
Cefuroxime should be given with care to patients receiving concurrent treatment with potent diuretics & who has history of colitis.
Therapeutic Class
Second generation Cephalosporins
Storage Conditions
Store in a cool, dry place (below 30o C), away from light and moisture. Keep out of the reach of children.
Common Questions about Cerox CV 500 mg Tablet
What is Cerox CV 500 mg Tablet?
Cefuroxime is the cephalosporin antibiotic and Clavulanic acid is a beta-lactamase inhibitor. Cerox CV 500 mg Tablet is indicated for the treatment of infections caused by sensitive bacteria.
What is Cerox CV 500 mg Tablet used for?
Cerox CV 500 mg Tablet is used to treat pharyngitis, tonsillitis, sinusitis, bronchitis, SSTI, UTI, gonorrhoea, pneumonia, typhoid fever.
How long does it take for Cerox CV 500 mg Tablet to take effect?
Cerox CV 500 mg Tablet starts working within 2-3 hours after taking it.
How long do the effects of this medicine last?
The effect of Cerox CV 500 mg Tablet lasts for an average duration of 4-8 hours.
Cerox CV 500 mg Tablet it safe to consume alcohol while taking this medicine?
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Is Cerox CV 500 mg Tablet a habit forming medicine?
No habit-forming tendencies were reported for Cerox CV 500 mg Tablet.
Can this medicine be taken during pregnancy?
Cerox CV 500 mg Tablet is safe to use in pregnancy to treat bacterial infections. However, it is recommended to use this medicine only after consulting your doctor.
Can Cerox CV 500 mg Tablet be taken while breast-feeding?
Cerox CV 500 mg Tablet is safe to use during breastfeeding. It enters into breast milk at low levels.
Quick Tips
- You have been prescribed Cerox CV 500 mg Tablet medicine to treat bacterial infections, even if they have developed resistance.
- Do not skip any doses and finish the full course of treatment even if you feel better. Stopping it early may make the infection to come back and harder to treat.
- Take it with food to avoid an upset stomach.
- Diarrhea may occur as a side effect. Taking probiotics may help. Talk to your doctor if you notice bloody stools or develop abdominal cramps.
- Stop taking Cerox CV 500 mg Tablet and inform your doctor immediately if you develop an itchy rash, swelling of the face, throat or tongue or breathing difficulties while taking it.
- Do not use leftover medicine for treating any infection in the future. Always consult your doctor before taking any antibiotic.
