ARISTO D3 (Cholecalciferol)
Vitamin D3 is essential for normal bone growth and development and to maintain bone density.
Description
Vitamin D3 is essential for normal bone growth and development and to maintain bone density. It is also necessary for utilization of both Calcium and Phosphorus. Vitamin D3 acts as a hormone and increases reabsorption of Calcium and Phosphorus by the kidney.
Presentation
ARISTO D3 2000 Tablet: Each tablet contains Cholecalciferol BP (as Vitamin D3) 2000 IU.
ARISTO D3 20000 Capsule: Each capsule contains Cholecalciferol BP (as Vitamin D3) 20000 IU.
ARISTO D3 40000 Capsule: Each capsule contains Cholecalciferol BP (as Vitamin D3) 40000 IU.
ARISTO D3 Oral & IM Injectable Solution: Each 1 ml ampoule contains Cholecalciferol BP (as Vitamin D3) 200000 IU.
Indications
Prevention and treatment of Vitamin D3 deficiency & Vitamin D3 deficiency related diseases.
Dosage & Administration
Use of Tablet & Capsule:
Curative treatment:
| Group of Patient | Dosages |
| Adult | 40000 IU/week for 7 weeks and followed by 2000 IU/day as maintenance therapy if required. |
| Child | 20000 IU in every 2 weeks for 6 weeks |
Curative treatment:
| Group of Patient | Dosages |
| Adult | 20000 IU/month |
| Child | 20000 IU in every 6 weeks |
Use of Oral & IM Injectable Solution:
Curative treatment:
| Disease | Dosages |
| Rickets | 1 ampoule every 2 weeks for one month then 1 ampoule for every 4 months |
| Osteoporosis | 1 ampoule every 2 weeks for 3 months |
| Osteomalacia | 1 ampoule every 2 weeks for 3 months |
| Tetany caused by hypocalcemia | 1 ampoule for every 4 months which may be increased to 2 ampoules |
| Menopause | 1 ampoule for every 6 months |
| Vitamin D deficiency | 1 ampoule can be repeated 1 to 6 months later |
Preventive measures:
| Period | Dosages |
| Pregnacy | 1/2 ampoule at 6th or 7th month |
| During Breast feeding | 1/2 ampoule for every 6 months |
| Children up to 5 years | 1 ampoule for every 6 months |
| Adolescent | 1 ampoule for every 6 months |
| Elderly | 1/2 ampoule for every 3 months |
– Injectable solution can be administered through IM or Oral route – Prevention should be started early and continued to the 5th year of life.
Contrainidications
Cholecalciferol is contraindicated in all diseases associated with hypercalcaemia. It is also contraindicated in patients with known hypersensitivity to Cholecalciferol (or medicines of the same class) and any of the constituent excipients. Cholecalciferol is contraindicated if there is evidence of vitamin D toxicity.
Warning & Precautions
People with the following conditions should exercise with caution when considering taking vitamin D3 supplements:
– High blood calcium or phosphorus level
– Heart problems
– Kidney disease
Vitamin D3 must be taken with adequate amounts of both calcium and magnesium supplementation.
Side effects
Generally all nutritional supplements are considered to be safe and well tolerable. However, few side-effects can generally occur including hypercalcaemia syndrome or calcium intoxication (depending on the severity and duration of hypercalcaemia), occasional acute symptoms include anorexia, headache, nausea, vomiting, abdominal pain or stomach ache and constipation with the administration of Cholecalciferol.
Drug interaction
Use in special groups
Use in special groups: Use in pregnancy: There is no evidence to suggest that vitamin D3 is teratogenic in humans even at very high doses. Cholecalciferol should be used during pregnancy only if the benefits outweigh the potential risk to the fetus.
Use in nursing mothers: It should be assumed that exogenous Cholecalciferol passes into the breast milk. In view of the potential for hypercalcaemia in the mother and for adverse reactions from Cholecalciferol in nursing infants, mothers may breastfeed while taking Cholecalciferol, provided that the serum Calcium levels of the mother and infant are monitored.
Packing
ARISTO D3 2000 Tablet: Each box contains 30 tablets in alu-alu blister pack.
ARISTO D3 20000 Capsule: Each box contains 10 capsules in alu-alu blister pack.
ARISTO D3 40000 Capsule: Each box contains 7 capsules in alu-alu blister pack.
ARISTO D3 Oral & IM Injectable Solution: Each box contains 1 ampoule of 1 ml Cholecalciferol BP (as Vitamin D3) solution.
