Apuldon (Domperidone)

Therapeutic Group : Gastroprokinetic Agent

Presentation:

Apuldon Tablet: Each tablet contains Domperidone Maleate BP equivalent to Domperidone 10 mg.
Apuldon Suspension: Each 5 ml contains Domperidone BP 5 mg.
Apuldon Paediatric Drops: Each ml contains Domperidone BP 5 mg.

Indications:

1. Stimulation of gut mobility: Non-ulcer dyspepsia, esophageal reflux, reflux esophagitis & gastritis, diabetic gastroparesis.
2. Prevention and symptomatic relief from acute nausea & vomiting in adults from any cause but especially in cytotoxic therapy & radiotherapy, associated with migraine attacks (in combination with analgesics) and L-dopa and bromocriptine treatment for Parkinsonian patients.
3. Functional dyspepsia.

Dosage & Administration:

The recommended oral dose for:
Adults: 10-20 mg every 4-8 hours daily.
Children (2-12 years): 0.2-0.4 mg/kg body weight (0.4-0.8ml paediatric drops/10 kg) every 4-8 hours daily.

Contrainidications:

Patients with a known allergy to Domperidone or Domperidone Maleate or any inactive ingredient of the product.

Warning & Precautions:

In case of children, treatment with Apuldon should be continued with caution because there may be increased risk of extra-pyramidal reactions in young children.

Side effects:

Apuldon may produce hyperprolactinemia which may cause galactorrhea & breast enlargement, soreness and reduced libido. It may rarely cause dry mouth, thirst, headache, nervousness, drowsiness, diarrhea, skin rash and itching.

Drug interaction:

Apuldon may reduce the hypoprolactinemic effect of bromocriptine. The effect of antimuscarinics & opioid analgesics may antagonize Apuldon on GI function.

Use in special groups:

Use in pregnancy: The safety of this drug has not been established for pregnant women. So it is not recommended during pregnancy.

Use in lactation: Apuldon may precipitate galactorrhea and improve postnatal lactation, which is secreted in breast milk but in very small quantities insufficient to be considered harmful.

Packing:

Apuldon Tablet: Each box contains 100 tablets in blister pack.
Apuldon Suspension: Each bottle contains 60 ml suspension.
Apuldon Paediatric Drops: Each bottle contains 15 ml drops.