Intimate®

Tadalafil
Phosphodiesterase type 5 (PDE-5) inhibitor (Anti-erectile dysfunction agent)

When sexual stimulation causes the local release of nitric oxide in the corpus cavernosum,
nitric oxide then activates the enzyme guanylyl cyclase, which results in increased levels of
cGMP. The increased levels of cGMP in the corpus cavernosum produce smooth muscle
relaxation and inflow of blood into the penile tissues, thereby producing an erection. PDE5
degrades cGMP in the corpus cavernosum, and the inhibition of PDE5 by Tadalafil
maintains increased levels of cGMP in the corpus cavernosum. Tadalafil has no effect on
penile blood flow in the absence of sexual stimulation.

Indication:

Intimate^TM is indicated for the treatment of erectile dysfunction (ED).
Intimate^TM is indicated for the treatment of the signs and symptoms of benign prostatic
hyperplasia (BPH).
Intimate^TM is indicated for the treatment of erectile dysfunction and the signs of benign
prostatic hyperplasia (ED/BPH).

Dosage & Administration:

For Use as Needed
• The recommended starting dose of Intimate^TM for use as needed in most patients is
10 mg, taken prior to anticipated sexual activity
• The dose may be increased to 20 mg or decreased to 5 mg, based on individual efficacy
and tolerability. The maximum recommended dosing frequency is once per day in most
patients.

For Once Daily Use
• The recommended starting dose of Intimate^TM for once daily use is 2.5 mg, taken at
approximately the same time every day, without regard to timing of sexual activity.
• The Intimate^TM dose for once daily use may be increased to 5 mg, based on individual
efficacy and tolerability.

Preparation:

Intimate 5 Tablet: Each box contains 10 tablets.
Intimate 10 Tablet: Each box contains 10 tablets.
Intimate 20 Tablet: Each box contains 4 tablets.