Lacicard (Lacidipine)

Therapeutic Group : Cardiovascular

Presentation:

Lacicard-2 Tablet: Each film coated tablet contains Lacidipine BP 2 mg.
Lacicard-4 Tablet: Each film coated tablet contains Lacidipine BP 4 mg.

Indications:

Treatment of hypertension, either alone or in combination with other antihypertensive agents such as beta-blockers and diuretics.

Dosage & Administration:

Initially 2 mg as a single daily dose, preferably in the morning; increased after 3-4 weeks to 4 mg daily, then if necessary to 6 mg.

Contrainidications:

Hypersensitivity to dihydropyridine derivatives. Cardiogenic shock, aortic stenosis, avoid within 1 month of myocardial infarction, impaired left ventricular function, pregnancy and breast-feeding.

Warning & Precautions:

Cardiac conduction abnormalities, poor cardiac reserve, hepatic impairment, withdraw if ischemic pain occurs shortly after initiating treatment or if cardiogenic shock develops, avoid grapefruit juice (may affect metabolism).

Side effects:

Flushing, palpitation, edema, headache, dizziness, rarely gastro-intestinal disturbances, gum hyperplasia, aggravation of angina, mood disturbances, asthenia, polyuria, muscle cramps, skin rash (including pruritus and erythema).

Drug interaction:

Cimetidine increases the concentration of Lacidipine. Lacidipine increases the concentration of Digoxin & Propranolol but Propranolol decreases the maximum concentration & AUC of Lacidipine.

Use in special groups:

Use in neonates: There are no data on safety or efficacy of Lacidipine in neonates.
Use in children: Treatment with Lacidipine have not been evaluated in Children.
Use in nursing mothers: Milk transfer studies showed that Lacidipine is excreted into breast milk and therefore, Lacidipine should not be used during lactation.
Use in pregnancy: Although no teratogenic effect of Lacidipine has been established in animals, there are no data on the safety of Lacidipine in human pregnancy; therefore it is contraindicated.

Packing:

Lacicard-2 Tablet: Each box contains 60’s tablets in Alu-Alu blister pack.
Lacicard-4 Tablet: Each box contains 30’s tablets in Alu-Alu blister pack.