Freecof (Dextromethorphan + Pseudoephedrine + Triprolidine)

Therapeutic Group : Bronchodilator & Antitussive

Presentation:

Freecof Syrup: Each 5 ml syrup contains Dextromethorphan Hydrobromide BP 10 mg, Pseudoephedrine Hydrochloride BP 30 mg & Triprolidine Hydrochloride BP 1.25 mg.

Indications:

Freecof is indicated for the symptomatic relief of upper respiratory tract disorders accompanied by non-productive cough.

Dosage & Administration:

Adults : 2 tea-spoon three times daily

Children:
Over 12 years: 2 tea-spoon three times daily.
6 to 12 years: 1 tea-spoon three times daily.
2 to 5 years: 1/2 tea-spoon three times daily.
6 months to 2 years: 1/4 tea-spoon three times daily or on advice of a physician only.

Contrainidications:

This syrup is contraindicated in-patients with a known hypersensitivity to its components. It is contraindicated in patients with severe hypertension or severe coronary artery disease. Patients being treated with monoamine oxidase inhibitors and within two weeks of stopping such treatment, ephedrine and other sympathomimetic agents as a hypertensive response may result. It is also contra-indicated in asthmatic patients during an attack of asthma.

Warning & Precautions:

This combination may cause drowsiness, and impair performance in tests of auditory vigilance. Patients should not drive or operate machinery until they have determined their own response. Although there are no objective data, users of this syrup should avoid the concomitant use of alcohol or other centrally acting sedatives. Although pseudoephedrine has virtually no pressor effects in patients with normal blood pressure, this syrup should be used with caution in patients taking antihypertensive agents, tricyclic antidepressant, other sympathomimetic agents such as decongestants, appetite suppressants and amphetamine-like psychostimulants. Caution should be exercised in patients with hypertension, heart disease, diabetes, hyperthyroidism, elevated intraocular pressure or prostatic enlargement.

Side effects:

Central nervous system depression or excitation may occur, drowsiness being reported most frequently. Sleep disturbance and rarely, hallucinations have been reported. Skin rashes with without irritation, tachycardia, dryness of mouth, nose and throat have occasionally been reported. Urinary retention has been reported occasionally in male patients in which prostatic enlargement could be an important predisposing.

Drug interaction:

Concomitant use of this syrup with sympathomimetic agents, such as decongestants, tricyclic antidepressants, appetite suppressants and amphetamine-like psychostimulants, or with monoamine oxidase inhibitors which interfere with the catabolism of sympathomimetic amines, may occasionally cause a rise in blood pressure. Because of its Pseudoephedrine Hydrochloride content, this syrup may partially reverse the hypotensive action of drugs which interfere with sympathetic activity including bretylium, bethanidine, guanethidine, debrisoquine, methyldopa and beta-adrenergic blocking agents.

Use in special groups:

Use in pregnancy: Although Pseudoephedrine Hydrochloride, Triprolidine Hydrochloride and Dextromethorphan Hydrobromide have been in use for many years without apparent ill consequence, there are no specific data on their use during pregnancy. Caution should therefore be exercised by balancing the potential benefit of treatment to the mother against any possible hazards to the developing fetus.

Packing:

Freecof Syrup: Each bottle contains 100 ml syrup.