Timex

ANXIOLYTICS & ANTIDEPRESSANT: Clomipramine HCl

Indication

Timex is indicated for the treatment of Obsessive-compulsive disorders, Phobias and panic attacks, Premature ejaculation, Cataplexy accompanying narcolepsy, Endogenous reactive, neurotic, organic, masked and involutional forms of depression, Depression associated with schizophrenia and personality disorders, Nocturnal enuresis.

Contraindication

Clomipramine Hydrochloride is contraindicated for patients known to have hypersensitivity to the drug.

Dosage & Administration

Treatment with Timex tablet should be initiated with a small dose of 25 mg given at bedtime for about a week followed by gradual increments to a maximum of 150 mg per day in adults and 75 mg per day in the elderly patients.

The drug should be administered in divided doses to minimize gastrointestinal disturbances, however in view of its long half-life it can be administered as a single dose at bedtime. The drug is not recommended for children.

Side Effect

Clomipramine Hydrochloride is generally well tolerated. The use of Clomipramine Hydrochloride is commonly associated with gastrointestinal disturbances, such as dry mouth, constipation, nausea, dyspepsia and anorexia.

Drug Interaction

The following drugs should be used with caution when concomitantly used with Clomipramine: Alcohol, Barbiturates and other CNS depressants, MAO-inhibitors, Anticholinergic and Sympathomimetic drugs, Guanethidine, Clonidine or similar agents.

Presentation

Timex tablet: Each box contains 3 x 10’s tablets in Alu-PVC strips.

Use Pregnancy Lactation

Pregnancy category C. Nursing Mothers: Clomipramine has been found to appear in human milk, therefore in view of the potential for adverse reactions, a decision should be made whether to continue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

Storage

Store below 30 ºC, keep in a dry place and protected from light. Keep all medicines out of reach of children.