Loricam

NSAIDs : Lornoxicam

Indication

Short-term relief of acute mild to moderate pain, symptomatic relief of pain and inflammation in osteoarthritis & symptomatic relief of pain and inflammation in rheumatoid arthritis.

Contraindication

Hypersensitivity to Lornoxicam or to any of the excipients, peptic ulcer, severe hepatic impairment, severe renal impairment (Serum creatinine > 700 µmol/l) and Thrombocytopenia and the third trimester of pregnancy.

Dosage & Administration

Acute Pain: 8-16 mg Lornoxicam daily divided into 2 or 3 doses. Maximum recommended daily dose is 16 mg. Osteoarthritis and Rheumatoid arthritis: Initial recommended dose is 12 mg Lornoxicam daily divided into 2 or 3 doses. Maintenance dose should not exceed 16 mg Lornoxicam daily. 

Side Effect

The most commonly observed adverse events of NSAIDs are gastrointestinal in nature. Peptic ulcers, perforation or GI bleeding, sometimes fatal, particularly in the elderly, may occur. Nausea, vomiting, diarrhea, flatulence, constipation, dyspepsia, abdominal pain, melaena, hematemesis, ulcerative stomatitis, exacerbation of colitis and Crohn’s disease have been reported by following administration of NSAIDs. 

Precaution

Lornoxicam should be taken carefully when someone has impaired kidney function, someone has a history of high blood pressure or heart failure, someone suffers from ulcerative colitis or Crohn’s diseases, someone has a history of bleeding tendency, someone has a history of asthma & someone suffers from SLE (Systemic Lupus Erythematosus) a rare immunological disease and women who are taking treatment for infertility.

Drug Interaction

Concomitant administration of Lornoxicam and combination with Vitamin K antagonists like warfarin increases the risk of bleeding. Combination with Cyclosporin can lead to reduced kidney function and to acute kidney injury in rare cases. Lornoxicam can also increase the adverse effects of lithium, methotrexate and digoxin and its derivatives. The effect of diuretics, ACE inhibitors and angiotensin Il receptor antagonists can be reduced in patients with heart failure.

Use Children

Lornoxicam is not recommended for use in children and adolescents below age 18 due to lack of data on safety and efficacy.

Use Pregnancy Lactation

Use in Pregnancy: Lornoxicam is contraindicated on the third trimester of pregnancy and should not be used during pregnancy in the first and second trimesters and delivery, as no clinical data on exposed pregnancies are available.

Use in Lactation: There are no data on the excretion of Lornoxicam in human breast milk. Lornoxicam is excreted in milk of lactating rats in relatively high concentrations. Therefore lornoxicam should not be used in breastfeeding women.

Storage

Store below 30 oC. Protect from light and moisture. Keep all medicines out of the reach of children.