Buflex
Generic Name: Nabumetone
Dosage Form: Tablet
TG Name: Musculoskeletal
1. What is BUFLEX®?
BUFLEX® is a preparation of Nabumetone, a nonsteroidal anti-inflammatory drug (NSAID) that exhibits anti-inflammatory and analgesic properties. It is indicated for acute and chronic treatment of signs and symptoms of osteoarthritis and rheumatoid arthritis along with musculoskeletal pain.
2. How does BUFLEX® work in our body?
Like other nonsteroidal anti-inflammatory agents, the mode of action of Nabumetone is not known; however, the ability to inhibit prostaglandin synthesis may be involved in the anti-inflammatory effect. The parent compound is a prodrug, which undergoes hepatic biotransformation to the active component, 6-methoxy-2-naphthyl acetic acid (6MNA), which is a potent inhibitor of prostaglandin synthesis.
3. What are the indications of BUFLEX®?
It is indicated for acute and chronic treatment of signs and symptoms of osteoarthritis and rheumatoid arthritis.
4. What is the dosage & administration of BUFLEX®?
For Osteoarthritis and Rheumatoid Arthritis: The recommended starting dose is 1,000 mg taken as a single dose with or without food. Some patients may obtain more symptomatic relief from 1,500 mg to 2,000 mg per day. Nabumetone can be given in either a single or twice-daily dose. Doses greater than 2,000 mg per day have not been studied. The lowest doses should be used for chronic treatment.
For Renal Impairment Patients: Caution should be used in prescribing Nabumetone to patients with moderate to severe renal insufficiency. A maximum starting dose of Nabumetone in patients with moderate or severe renal insufficiency should not exceed 750 mg or 500 mg, respectively once daily. Following careful monitoring of renal function in patients with moderate or severe renal insufficiency, daily doses may be increased to a maximum of 1,500 mg and 1,000 mg, respectively.
5. What are the contraindications of BUFLEX®?
- Hypersensitivity to Nabumetone
- NSAIDs induce asthma, urticarial, or other allergic-type reaction
6. What are the adverse effects of BUFLEX®?
- Gastrointestinal: Diarrhea, dyspepsia, abdominal pain, constipation, flatulence, nausea, positive stool guaiac, dry mouth, gastritis, stomatitis, vomiting
- Central Nervous System: Dizziness, headache, fatigue, increased sweating, insomnia, nervousness, somnolence
- Dermatologic: Pruritus, rash
- Special Senses: Tinnitus
- Miscellaneous: Edema
7. What would be the storage condition of BUFLEX®?
Do not store above 30°C. Do not refrigerate or freeze. Keep in a dry place. Protect from light & keep out of the reach of children.
