Deflux

Generic Name: Domperidone Dispersible
Dosage Form: Tablet, Meltab, Suspension & Paediatric Drops
TG Name: Gastrointestinal

What Deflux^® Meltab is and what it is used for?
Deflux^® Meltab (Melt-in-Mouth Tab) is a preparation of Domperidone 10 mg.It is an advanced tablet formulation with DuraSolv technology used for faster relief from-

• Dyspepsia
• Nausea & Vomiting
• Esophageal reflux & gastritis
• Diabetic Gastroparesis
• Stomach Discomfort
• Fullness & Bloating
• Prophylactic treatment of migraine

Before you take Deflux^® Meltab
Do not take this medicine and tell your doctor.
If you:

• are allergic (hypersensitive) to domperidone or any of the other ingredients of this medicine
• have stomach bleeding or if you regularly have severe abdominal pain or persistent black stools
• have a blocked or perforated gut
• have a tumor of the pituitary gland (prolactinoma)
• have a disorder known as phenylketonuria (a metabolic disorder)
• have a moderate or severe liver disease
• have an ECG (electrocardiogram) that shows a heart problem called “prolonged QT interval”
• have or had a problem where your heart cannot pump the blood around your body as well as it should (condition called heart failure)
• have a problem that gives you a low level of potassium or magnesium, or a high level of potassium in your blood

How to take Deflux^® Meltab
Always use this medicine exactly as your doctor has told you. Check with your doctor or pharmacist if you are not sure.The usual dose is 10-20 mg every 4-8 hours daily in divided dose, if possible before meals.
If you have used or taken too much of this medicine, contact your doctor, pharmacist or the poison centre immediately, in particular if a child has taken too much.
Take your medicine as soon as you remember. If it is almost time for your next dose, wait until that is due and then continue as normal. Do not take a double dose to make up for a forgotten dose.

Possible side effects
Like all medicines, this is medicine can cause side effects, although not everybody gets them.Stop using this medicine and contact your doctor immediately if you experience any of the following unwanted events.

• Seizures
• Involuntary movements of the face or arms and legs, excessive trembling, excessive muscle stiffness or muscle spasm
• A severe hypersensitivity reaction that may occur soon after administration that is characterised by skin rash, hives, itching, flushing, fainting, a swollen face and difficulty breathing among other possible symptoms (anaphylactic reaction)
  
  Common side effects:
  • Dry mouth
  
  Uncommon side effects:
  • Anxiety
  • Loss of interest in sex or diminished interest in sex
  • Headache
  • Sleepiness
  • Diarrhoea
  • Rash
  • Itchiness
  • Painful or tender breasts
  • Milk discharge from breasts
  • A general feeling of weakness

Tell your doctor if any of the side effects gets serious or lasts longer than a few days, or if you notice any side effects

Pregnancy and Lactation
Pregnancy: It is not known whether the use of this medicine is harmful during pregnancy. If you are pregnant or think you may be you should inform your doctor who will decide if you can take this medicine.
Lactation: Small amounts of Domperidone have been detected in breast milk.
Domperidone should be used during breast-feeding only if your doctor considers this clearly necessary. Ask your doctor for advice before taking this medicine.

Warnings & PrecautionTake special care with this medicine,
If you:

• suffer from liver problems (liver function impairment or failure)
• suffer from kidney problems (kidney function impairment or failure)
• are older than 60 years of age

Do not take this medicine if you are taking medicine to treat:

• fungal infections e.g. pentamide, azole anti-fungals, specifically itraconazole, oral ketoconazole, fluconazole, poconazole or voriconazole
• bacterial infections, specifically erythromycin, clarithromycin, telithromycin, levofloxacin, moxifloxacin, spiramycin (these are antibiotics)
• heart problems or high blood pressure (e.g., amiodarone, dronedarone, ibutilide, disopyramide dofetilide, sotalol, hydroquinidine, quinidine)
• psychoses (e.g., haloperidol, pimozide, sertindole)
• depression (e.g., citalopram, escitalopram)
• gastro-intestinal disorders (e.g., cisapride, dolasetron, prucalopride)
• allergy (e.g., mequitazine, mizolastine)
• malaria (in particular halofantrine, lumefantrine)
• AIDS/HIV such as ritonavir, saquinavir or teleprevir (these are protease inhibitors)
• cancer (e.g., toremifene, vandetanib, vincamine)
• if you are taking certain other medicines (e.g. bepridil, diphemanil, methadone)

Deflux^® Meltab with food and drink: Take Deflux^® Meltab before meals, as when taken after meals, the absorption of the medicine is slightly delayed.

How to store Deflux^® Meltab
Keep this medicine out of the sight and reach of children.Do not store above 25°C (room temperature). Do not freeze.