No-Spa Injection

Drotaverine Hydrochloride

Indications

Gastric, Intestinal or pyloric spasm, cholelithiasis and spastic constipation, to relieve tenesmus in dysentry, dysmenorrhoea, peripheral vascular disorders. Owing to its freedom from cardiotoxic and hypotensive effects, No-Spa HCl has outstanding value in the treatment of coronary insufficiency and angina pectoris.

Pharmacology

Drotaverine HCl is a new potent synthetic antispasmodic drug which is readily absorbed from the intestine. Like papaverine, it acts directly on the smooth muscle fibers exceeding however, the antispasmodic effect of the standard preparations. Drotaverine HCl is characterized by its rapid onset of actions which has advantage in cases of acute painful spastic conditions. In addition to its spasmolytic and vasodilatory actions, Drotaverine HCl elicits a selective blockage of cardiac beta-receptors.

Dosage & Administration

The usual dose for adults is 1 to 2 tablets three times daily, one to three times 2 to 4 ml injection subcutaneously or intramuscularly. In case of acute stone colic 2 to 4 ml may be given by slow intravenous injection, in case of peripheral arterial spasm or obstruction Drotaverine HCl may be injected intra arterially. Children should be given smaller doses according to age and body weight. Children should receive once or twice daily 1/4 to 1/2 tablet, adolescent 1/2 to 1 tablet daily. In peptic ulcer it is expedient to combine Drotaverine HCl with atropine or atropine-like compounds.

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Interaction

May attenuate the action of levodopa. Concurrent use of analgesics, antimuscarinics or benzodiazepines. Additive beneficial effect with concurrent use of analgesics, antimuscarinics or benzodiazepines.

Contraindications

It is contraindicated in patients with a history of hypersensitivity to Drotaverine HCl.

Side Effects

In rare cases nausea and vertigo may occur.

Pregnancy & Lactation

There is no known case of teratogenecity in animal studies. However, the use of drotaverine should be avoided during pregnancy and lactation.

Precautions & Warnings

Caution should be taken for patients suffering from liver and kidney disease.

Therapeutic Class

Anticholinergics

Storage Conditions

To be dispensed only by or on the prescription of a registered physician. Keep out of reach of children. Keep in a cool, dry place.