Set 101(Tolfenamic acid )
Therapeutic Group: Animal Health
Presentation
Set 101 vet injection 10 ml: Each ml injection contains Tolfenamic acid BP 40 mg.
Description
Tolfenamic Acid is a member of the anthranilic acid derivatives (or fenamate) class of (NSAIDs) drugs. Tolfenamic acid is a non-steroidal anti-inflammatory drug (NSAIDs) and cyclo-oxygenase inhibitor. It is used for the management of both acute and chronic pain in animals. The pharmacologic effects of Tolfenamic Acid are similar to those of aspirin. It inhibits prostaglandin release and has a direct inhibitory effect on prostaglandin receptors. It also decreases platelet aggregation. Tolfenamic acid is well-absorbed. It is generally used as a once a day and peak levels occurring at two to four hours after administration.
Indications
Anti-inflammatory, anti-pyretic and analgesic agent. In case of cattle: as an adjunct in the treatment of acute mastitis used in conjunction with antibacterial therapy, in the control of acute inflammation associated with bacterial respiratory disease.
Dosage & Administration
Cattle: In case of bovine mastitis and other inflammation recommended dose is 4 mg/kg (1 ml/10 kg bwt) as a single IV or IM injection. For use in bovine respiratory disease is 2 mg/kg bwt (1 ml/20 kg bwt) by IM or IV injection. Treatment may be repeated after 48 hours. If a second injection required it should be given in the opposite side of the animal’s body.
Or as directed by the registered Veterinarian.
Side Effects
Well tolerable at recommended dose. Sometimes dysuria (in males), Diarrhea, nausea, epigastric pain, erythema, headache, tremor, euphoria, fatigue, & haematuria may occur
Precautions
Do not exceed the stated dose or the duration. Do not exceed 20 ml per intramuscular injection site.
Use in Pregnancy & Lactation
In limited studies so far available, NSAIDs can appear in milk in very low concentrations. Use of the product in pregnant and lactating animals should be at the consideration made by veterinarian after analyzing risks and benefits.
Drug Interaction
It decreases antihypertensive response to loop diuretics, β-blockers and ACE inhibitors. It also increases the risk of nephrotoxicity
Over Dose
Well tolerable at recommended dose. Sometimes dysuria (in males), Diarrhea, nausea, epigastric pain, erythema, headache, tremor, euphoria, fatigue, & haematuria may occur. In cases of significant poisoning acute renal failure and liver damage are possible.
Withdrawal Period
Meat: 3 day following IV administration and 7 days following IM or SC administration, Milk: 1 day.
Storage
Do not store above 30 °C, avoid freezing. Store the vial in the carton to protect from light. Keep out of the reach of children.
Commercial Pack
Set 101 vet injection: Each commercial box contains 1 vial of 10 ml.
