Consucon 80(Gliclazide tablet)

Therapeutic Group: Others

Presentation

Consucon 80 : Each tablet contains Gliclazide BP 80 mg.

Description

Gliclazide (Consucon 80) is a second generation sulfonylurea drug that has hypoglycaemic and potentially useful haemobiological properties. It stimulates the release of insulin from pancreatic -cells by facilitating Ca+2 transport across the -cell membranes and decreases hepatic glucose output.

Indications

Gliclazide (Consucon 80) is indicated for the treatment of maturity onset diabetes mellitus (NIDDM) patients who require oral hypo-glycaemic drug.

Dosage & Administration

Oral route : The usual initial dose is 40 to 80 mg daily. The dose can be increased upto 320 mg daily in divided doses when needed. The drug should be taken before meal. For children Gliclazide is not used because it is contraindicated in juvenile-onset diabetes.

Side Effects

There may be hypoglycaemia in concurrent conditions such as hepatic and renal disease, malnutrition,
alcohol intoxication. Sometimes headache, gastrointestinal upsets, nausea, dizziness, skin reactions
including rash, pruritus, erythema may occur.

Precautions

Gliclazide should be used carefully in patients with hepatic impairment. If there is definite hepatic disease then gliclazide should not be used. Gliclazide can be used safely in patients with renal insufficiency as it is extensively metabolized. Gliclazide (Consucon 80) has less sudden hypoglycaemic episode than other sulfonylurea group of drugs.

Use in Pregnancy & Lactation

Gliclazide is contraindicated in pregnant women. It should not be used in breast feeding mother.

Drug Interaction

The hypoglycaemic effects of Gliclazide (Consucon 80) may be increased by Aspirin, NSAIDs, Phenylbutazone, Clofibrate, Sulfonamide, Cimetidine, Imidazole antifungal agents and Monoamine Oxidase inhibitors. The hypoglycaemic effect of Gliclazide (Consucon 80) some times may be reduced by Rifampin, Barbiturates, Phenytoin, Thiazide diuretics, Diazoxide, Glucocorticoids, Estrogens, Sympathomimetic drugs and occasionally Alcohol.

Over Dose

In accidental overdose, at first gastric lavage should be done and at the same time the hypoglycaemia should be corrected. In severe cases I/V infusion of 5% glucose should be started immediately with frequent monitoring of blood glucose and potassium level.

Storage

Store in a cool and dry place, below 30°C and away from light.

Commercial Pack

Consucon 80 : Box containing 5 blister strips of 10 tablets.