Dexaguard Eye Drops(Dexamethasone 0.1% & Chloramphenicol 0.5%)

Therapeutic Group: Ophthalmic

Presentation

Each ml eye drops contain Dexamethasone Sodium Phosphate BP equivalent to Dexamethasone 1 mg and Chloramphenicol BP 5 mg.

Description

Dexamethasone is one of the most potent corticosteroids; it is 5 -14 times more potent than prednisolone and 25 – 75 times more potent than cortisone and hydrocortisone. Of paramount importance with regard to local therapy is the fact that dexamethasone is over 2000 times more soluble than hydrocortisone or prednisolone. The addition of chloramphenicol, a broad-spectrum antibiotic, has made this combination yield excellent results in inflammation of the anterior uvea.

Indications

Acute purulent conjunctivitis; fresh inflammation of the superficial and deeper corneal layers and corneal ulceration. Keratitis disciformis and the more deep-seated forms of post-herpetic keratitis. Allergic conjunctivitis, allergic blepharitis. Acute and chronic iritis and iridocyclitis.

Dosage & Administration

One drop, 1 to 4 times daily, into the lower fornix

Side Effects

The local use of dexamethasone over a prolonged period may lead in some cases to secondary glaucoma and the development of complicated cataract

Precautions

Dexamethasone and Chloramphenicol Eye drops must be used under strict medical supervision. Because of the possibility of inducing corneal abscess, fungal keratopathy or glaucoma the patient should be referred to an ophthalmologist if the eye has not responded within 48 hours.

Use in Pregnancy & Lactation

Pregnancy The safety of this combination during pregnancy has not yet been established.
Lactation It is not known whether this ophthalmic suspension is excreted in human milk; therefore caution should be observed when it is administered to a nursing mother

Drug Interaction

Specific drug interaction studies have not been conducted with this combination.

Over Dose

If a rise of intraocular pressure occurs, the treatment has to be discontinued

Commercial Pack

Dexaguard Sterile Eye Drops: Plastic dropper bottle containing 5ml sterile Eye Drops.