Bestron(Conjugated Estrogens)

Therapeutic Group: Hormone replacement therapy

Presentation

Bestron : Each tablet contains Conjugated Estrogens USP 0.45 mg and Bazedoxifene INN 20 mg.

Description

Bestron is a combination of Conjugated Estrogens with Bazedoxifene. Conjugated Estrogens and Bazedoxifene function by binding to and activating estrogen receptors (ER) α and β. Bazedoxifene is an estrogen agonist / antagonist that acts as an agonist in some estrogen-sensitive tissues and an antagonist in others (e.g. uterus).

Indications

Bestron is indicated for treatment of moderate to severe vasomotor symptoms associated with menopause and prevention of postmenopausal osteoporosis.

Dosage & Administration

Take Bestron once daily, without regard to meals. Tablets should be swallowed whole. Women taking Bestron for prevention of postmenopausal osteoporosis should add supplemental calcium and/or vitamin-D to their diet if daily intake is inadequate.

Side Effects

High blood pressure, blood clots, liver problems, thyroid problems, fluid retention, hypocalcemia, dementia, breast lumps, unusual vaginal bleeding, severe headache, muscle spasms, weakness and fatigue, nausea, diarrhea, throat pain, dizziness etc.

Precautions

Women taking Bestron should not take progestins, additional estrogens or additional estrogen agonist/antagonists. All women should receive yearly breast examinations by a healthcare provider and perform monthly breast self-examinations. In addition, mammography examinations should be scheduled based on patient age, risk factors, and prior mammogram results.

Use in Pregnancy & Lactation

Pregnancy: Pregnancy Category X. Bestron must not be used in women who are or may become pregnant.
Lactation: Bestron should not be used by lactating women. It is not known whether this drug is excreted in human milk. Estrogen administration to nursing mothers has been shown to decrease the quantity and quality of the milk.

Over Dose

In case of overdosage, there is no specific antidote, and the treatment should be symptomatic. Symptoms of overdosage of estrogen-containing products may include nausea, vomiting, breast tenderness, dizziness, abdominal pain, fatigue; withdrawal bleeding may occur.

Storage

Do not store above 30 ºC. Keep away from light and out of the reach of children. After opening foil pouch, product must be used within 60 days.

Commercial Pack

Bestron : Each box contains 2 Alu-PVDC blister strips of 10 tablets.